The Shotlee Journal
Expert insights on GLP-1 medications, peptide therapy, and evidence-based approaches to weight management.
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Ozempic has transformed weight loss, but is it too good to be true? Galway author Aimee Donnellan's 'Off the Scales' uncovers the science, overlooked pioneers, and real patient stories behind GLP-1 injections. Discover the benefits, serious risks like muscle loss, and what happens when you stop.
Alzheimer's disease may be more than just amyloid plaques—emerging evidence points to brain insulin resistance as a core driver, earning it the label 'Type 3 diabetes.' A recent Polish study uncovers how impaired insulin signaling starves neurons of energy and accelerates toxic protein buildup. Discover the science and potential therapies like GLP-1 agonists that could change the game.
Roche is advancing CT-388, a dual GLP-1/GIP agonist, after Phase 2 results showed impressive weight loss comparable to Eli Lilly's Zepbound. With the obesity market booming, can this injectable stand out against Wegovy and emerging orals? Dive into the data and what it means for patients.
Stopping Ozempic or Wegovy often leads to significant weight regain within 1-1.5 years, reversing gains in blood sugar, pressure, and cholesterol. Experts explain the science behind this, from metabolic adaptation to surging appetite. Understand how to approach GLP-1 therapy for long-term success.
Medicare is breaking its long-standing rule against covering weight loss drugs like Wegovy and Zepbound through a new GLP-1 initiative. Starting with a bridge phase in July 2026, eligible beneficiaries could pay just $50 monthly copays—if they act now. This guide explains the changes, requirements, and clinical context for GLP-1 therapy.
Karren Brady, the 56-year-old Apprentice star and baroness, has slammed 'belittling' Ozempic rumors about her slimmer figure. She attributes her transformation to cycling, walking, and healthy eating. Discover the truth behind GLP-1 medications and how to achieve lasting weight loss naturally or with meds.
Many users like the author experience devastating weight regain shortly after stopping Mounjaro, mirroring real-world and trial data. This guide unpacks the physiology, backed by studies, and offers practical steps to sustain your progress. Don't let hard-won losses slip away—arm yourself with knowledge.
GLP-1 medications like semaglutide and tirzepatide deliver impressive weight loss, but fears of muscle wasting persist. Clinical evidence reveals these drugs cause modest, proportional lean mass changes while enhancing muscle quality. Discover the science and practical steps to optimize outcomes.
GLP-1 medications like Ozempic, Wegovy, Mounjaro, and Zepbound now make up over 7% of U.S. prescriptions, fueling weight loss trends but raising safety concerns. From FDA warnings on sharing pens to charges over fake drugs, here's what patients need to know. Discover emerging research and tools to manage your therapy safely.
