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📖Complete Guide✅Updated 2026🔬Evidence-Based

Setmelanotide Guide

FDA-Approved MC4R Agonist for Genetic

Complete guide to Setmelanotide. Setmelanotide (brand name IMCIVREE) is an FDA-approved melanocortin 4 receptor (MC4R) agonist developed by Rhythm.

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POMC/PCSK1 (52 wks)
~10%+
Hunger Reduction
Dramatic
Significant weight loss and dramatic hunger reduction in patients with POMC or PCSK1 deficiency obesity.
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
SetmelanotideB12
SETMELANOTIDE
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Setmelanotide
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
SetmelanotideRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
SetmelanotideB12
SETMELANOTIDE
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Setmelanotide
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
SetmelanotideRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01BACKGROUND

FDA-Approved MC4R Agonist for Genetic Obesity (IMCIVREE)

Setmelanotide (brand name IMCIVREE) is an FDA-approved melanocortin 4 receptor (MC4R) agonist developed by Rhythm Pharmaceuticals. Unlike GLP-1 medications that target appetite through incretin pathways, setmelanotide directly activates the MC4R pathway in the hypothalamus — the brain\'s primary appetite regulation center. It is specifically approved for rare genetic obesity disorders caused by POMC, PCSK1, or LEPR deficiency, with expansion studies ongoing for Bardet-Biedl syndrome and other genetic conditions. Use the Shotlee app to track your current protocol and build baseline data for whatever comes next.

02DEEP DIVE

What Is Setmelanotide?

Setmelanotide (brand name IMCIVREE) is an FDA-approved melanocortin 4 receptor (MC4R) agonist developed by Rhythm Pharmaceuticals. Unlike GLP-1 medications that target appetite through incretin pathways, setmelanotide directly activates the MC4R pathway in the hypothalamus — the brain\'s primary appetite regulation center. It is specifically approved for rare genetic obesity disorders caused by POMC, PCSK1, or LEPR deficiency, with expansion studies ongoing for Bardet-Biedl syndrome and other genetic conditions.

Track your current protocol in Shotlee while this science evolves. Having clean historical data means you can compare outcomes with precision if you ever switch medications.

03WHAT TO TRACK

How It Works

01
🔬
MC4R Activation
Directly targets brain appetite center. Restores broken satiety signaling. Bypasses incretin pathways. Track hunger patterns in Shotlee
02
🔬
Genetic Obesity Focus
POMC deficiency obesity. PCSK1 deficiency obesity. LEPR deficiency obesity. Log genetic therapy in Shotlee
03
🧬
Unique Mechanism
Not a GLP-1 or amylin drug. Melanocortin pathway restoration. Daily subcutaneous injection. Monitor all protocols in Shotlee
04
🔬
Why This Matters
Setmelanotide is the first precision medicine for genetic obesity, directly restoring the broken MC4R signaling that causes insatiable hunger in affected patients. It represents a fundamentally differ
04KEY NUMBERS

Clinical Data

📈
POMC/PCSK1 (52 wks)
0%+
💪
Hunger Reduction
0Dramatic
Significant weight loss and dramatic hunger reduction in patients with POMC or PCSK1 deficiency obesity.
05MECHANICS

Side Effects

1
Injection site reactions
2
Skin hyperpigmentation (common)
3
Spontaneous penile erections (males)
4
Track all effects in Shotlee
06WHAT TO TRACK

Vital Protocol FAQs

01
🔬
Is Setmelanotide for general obesity?
Currently, IMCIVREE is FDA-approved specifically for rare genetic obesity caused by POMC, PCSK1, or LEPR pathway deficiencies. Expansion studies for other genetic obesity forms are ongoing. Track your
02
🧬
How is it different from GLP-1 drugs?
Completely different mechanism. Setmelanotide activates MC4R in the brain\'s hypothalamus to restore broken appetite signaling, while GLP-1 drugs work through incretin hormone pathways. Use Shotlee to
07FAQ

Guide FAQs

Complete guide to Setmelanotide. Setmelanotide (brand name IMCIVREE) is an FDA-approved melanocortin 4 receptor (MC4R) agonist developed by Rhythm.

Yes. Shotlee supports tracking Setmelanotide doses, side effects, and health metrics. It is free to use.

Free · Always

Track Your Setmelanotide Protocol in Shotlee

Free dose logging, side effect tracking, and health metric monitoring for your complete protocol.

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📚References & sources

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