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📖Complete Guide✅Updated 2026🔬Evidence-Based

Icosema Guide

Novo Nordisk

Complete guide to Icosema. Icosema is Novo Nordisk

Download on theApp Store
Get it onGoogle Play
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
IcosemaB12
ICOSEMA
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Icosema
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
IcosemaRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
IcosemaB12
ICOSEMA
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Icosema
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
IcosemaRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01BACKGROUND

Novo Nordisk\'s Fixed-Ratio Insulin Icodec + Semaglutide Combination

Icosema is Novo Nordisk\'s investigational fixed-ratio combination of insulin icodec (a once-weekly basal insulin) and semaglutide (a GLP-1 receptor agonist). By combining both in a single weekly injection, it aims to simplify diabetes management while providing the metabolic benefits of GLP-1 therapy alongside insulin\'s glucose-lowering power. Use the Shotlee app to track your current protocol and build baseline data for whatever comes next.

02DEEP DIVE

What Is Icosema?

Icosema is Novo Nordisk\'s investigational fixed-ratio combination of insulin icodec (a once-weekly basal insulin) and semaglutide (a GLP-1 receptor agonist). By combining both in a single weekly injection, it aims to simplify diabetes management while providing the metabolic benefits of GLP-1 therapy alongside insulin\'s glucose-lowering power.

Track your current protocol in Shotlee while this science evolves. Having clean historical data means you can compare outcomes with precision if you ever switch medications.

03WHAT TO TRACK

How It Works

01
🔬
Insulin Icodec
Once-weekly basal insulin. Steady glucose control. Reduces injection burden. Track insulin data in Shotlee
02
🔬
Semaglutide Component
GLP-1 receptor agonist. Appetite suppression. Weight management benefits. Log weight trends in Shotlee
03
✅
Combination Advantage
Single weekly injection. Simplified regimen. Dual metabolic action. Monitor both effects in Shotlee
04
🔬
Why This Matters
Managing both insulin and GLP-1 therapy in a single weekly injection dramatically simplifies treatment for people with Type 2 diabetes. Tracking dose adherence and metabolic markers in Shotlee ensures
04DEEP DIVE

Clinical Data

Multiple Phase 3 trials (COMBINE program) are evaluating Icosema in Type 2 diabetes populations.

05MECHANICS

Side Effects

1
Hypoglycemia (insulin component)
2
GI symptoms (semaglutide component)
3
Injection site reactions
4
Track all side effects in Shotlee
06WHAT TO TRACK

Vital Protocol FAQs

01
🔬
What is Icosema?
Icosema is a fixed-ratio combination of once-weekly insulin icodec and semaglutide in a single injection. It is designed for people with Type 2 diabetes. Track your insulin and GLP-1 protocols togethe
02
🔬
Is Icosema approved?
Icosema is still in Phase 3 trials. Use Shotlee to track your current insulin and GLP-1 protocols while awaiting results.
07FAQ

Guide FAQs

Complete guide to Icosema. Icosema is Novo Nordisk

Yes. Shotlee supports tracking Icosema doses, side effects, and health metrics. It is free to use.

Free · Always

Track Your Icosema Protocol in Shotlee

Free dose logging, side effect tracking, and health metric monitoring for your complete protocol.

Download on theApp Store
Get it onGoogle Play

📚References & sources

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