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📖Complete Guide✅Updated 2026🔬Evidence-Based

Amycretin Guide

Novo Nordisk

Complete guide to Amycretin. Amycretin is Novo Nordisk

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SC 20mg (36 wks)
-22.0%
Oral (12 wks)
-13%
T2D SC (36 wks)
-14.5%
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
AmycretinB12
AMYCRETIN
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Amycretin
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
AmycretinRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
Dashboard
Your complete health overview in one place
🔥
14-day streak
Logged 18 of 18 scheduled shots
Next Shot Reminder
⌄
ACTIVE MEDICATIONS
AmycretinB12
AMYCRETIN
🔥 14
2
days away
Thursday · 7.5mg
⌄
Medication Supply
Amycretin
6.2 / 10 mg · Vial
~42 days left · Mar 15
B12
4.4 / 5 ml · Vial
~88 days left · May 8
Retatrutide
1.2 / 5 mg · Vial
~6 days left · refill soon
Medication Levels
7 Days2 Weeks1 Month90 Days
CURRENT LEVEL
5.42mg
Mar 6
Today
ACTIVE MEDICATIONS
AmycretinRetatrutide
0mg2.7mg5.4mg
18
Total Injections
💉 All time
122/78
Average BP
🩺 mmHg
8.4
Avg Mood
😊 /10
Health Chart
1mAll
218.6lb
↓ 8.4 lb · 3.7%
WeightInjectionsBPMood
2282222162102277.5mg7.5mg4mg10mg218
Feb 6Feb 14Feb 22Mar 2Today
Photos
12 photos · 2w streak
Week 1
Week 7
Today
Scheduled Reminders
Weight
Due today
Mood
Done
Blood Pressure
Tomorrow
Body Measurements
In 3 days
01BACKGROUND

Novo Nordisk\'s Dual GLP-1 + Amylin Agonist

Amycretin is Novo Nordisk\'s investigational dual GLP-1 and amylin receptor agonist. Unlike single-mechanism GLP-1 drugs, amycretin simultaneously activates both the GLP-1 and amylin pathways, combining appetite suppression from two different hormonal systems. In Phase 1b/2a trials, the subcutaneous form showed 22% weight loss at the highest dose over just 36 weeks, with an oral formulation also in development. Use the Shotlee app to track your current protocol and build baseline data for whatever comes next.

02DEEP DIVE

What Is Amycretin?

Amycretin is Novo Nordisk\'s investigational dual GLP-1 and amylin receptor agonist. Unlike single-mechanism GLP-1 drugs, amycretin simultaneously activates both the GLP-1 and amylin pathways, combining appetite suppression from two different hormonal systems. In Phase 1b/2a trials, the subcutaneous form showed 22% weight loss at the highest dose over just 36 weeks, with an oral formulation also in development.

Track your current protocol in Shotlee while this science evolves. Having clean historical data means you can compare outcomes with precision if you ever switch medications.

03WHAT TO TRACK

How It Works

01
🔬
GLP-1 Agonism
Reduces appetite centrally. Slows gastric emptying. Enhances insulin secretion. Proven pathway (Ozempic/Wegovy)
02
🔬
Amylin Agonism
Promotes satiety signaling. Controls gastric emptying. Suppresses post-meal glucagon. Complementary to GLP-1
03
🔬
Dual Synergy
Two pathways working together. Potentially superior weight loss. Available as oral AND injectable. Track dual-agonist results in Shotlee
04
🔬
Why This Matters
By combining GLP-1 and amylin signaling in a single molecule, amycretin attacks appetite and metabolism from two angles simultaneously. The oral formulation showing 13% weight loss in just 12 weeks is
04KEY NUMBERS

Clinical Data

📈
SC 20mg (36 wks)
−0.0%
💪
Oral (12 wks)
−0%
🏆
T2D SC (36 wks)
−0.0%
05MECHANICS

Side Effects

1
Nausea (mild to moderate)
2
GI symptoms consistent with GLP-1 class
3
Generally well tolerated
4
No major safety signals
06WHAT TO TRACK

Vital Protocol FAQs

01
🔬
Is Amycretin a GLP-1 or amylin drug?
It is both. Amycretin is a dual GLP-1 and amylin receptor agonist, meaning it activates two different hormone pathways simultaneously. This makes it mechanistically distinct from pure GLP-1 drugs like
02
🔬
Can I get Amycretin now?
No, Amycretin is still investigational. Phase 3 trials are expected to begin in Q1 2026. Use Shotlee to track your current protocol and build baseline data.
03
🔬
Will there be an oral version?
Yes, Novo Nordisk is developing both subcutaneous and oral formulations. The oral version showed 13% weight loss in just 12 weeks in Phase 1. Track your progress in Shotlee regardless of formulation.
07FAQ

Guide FAQs

Complete guide to Amycretin. Amycretin is Novo Nordisk

Yes. Shotlee supports tracking Amycretin doses, side effects, and health metrics. It is free to use.

Free · Always

Track Your Amycretin Protocol in Shotlee

Free dose logging, side effect tracking, and health metric monitoring for your complete protocol.

Download on theApp Store
Get it onGoogle Play

📚References & sources

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